publications
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ORCID click here
Bydak B, Pierdoná TM, Seif S, Sidhom K, Obi PO, Gordon JW and SALEEM A. Profiling skeletal muscle-derived extracellular vesicles with differentiation and acute contractile activity. BioRxiv. doi: xxxxx, 2022.
Pierdoná TM, Martin A, Obi PO, Seif S, Bydak B, Eadie A, Brunt K, McGavock J, Sénéchal M and SALEEM A. Extracellular vesicles as predictors of individual response to exercise training in youth living with obesity. Frontiers in Physiology, 2022. MS under review.
Preprint - bioRxiv. MS ID#: BIORXIV/2020/390872. 2020 doi: https://doi.org/10.1101/2020.11.20.390872
Martens MD, Seshadri N, Nguyen L, Chapman D, Hensen ES, Xiang B, Mendoza A, Rattan S, Gibson SB, SALEEM A, Hatch GM, Doucette CA, Karch JM, Dolinsky VW, Dixon IM, West AR, Rampitsch C, and Gordon JW. Misoprostol Treatment Prevents Hypoxia-Induced Cardiac Dysfunction Through a 14-3-3 and PKA regulatory motif on Bnip3. Cell Death Dis, 12, 1105, 2021, https://doi.org/10.1038/s41419-021-04402-3
Preprint -
Haricharan S, Raghavan S, and SALEEM A. The Worth of a Scientist. Nat Commun 2021, MS# NCOMMS-21-25647. MS under review.
Obi PO, Kent JE, Jeyaraman MM, Askin A, Pierdoná TM, Halayko AJ and SALEEM A. The Therapeutic Effect of Extracellular Vesicles on Asthma in Pre-clinical Models: A Systematic Review Protocol. J. Respir. 2021, 1(1), 84-95; https://doi.org/10.3390/jor1010009.
Preprint - Preprints 2020, 2020070349, doi: https://www.preprints.org/manuscript/202007.0349/v1
Reyes SM, Miliku K, Chan D, Brockway M, Turner S, Raimondi C, Kearns K, SALEEM A, Kelly LE, Nickel N, and Azad MB. Messaging and methodological considerations when researching breastfeeding and obesity. Eur J of Clin Nutr 2021. doi: https://doi.org/10.1038/s41430-021-00867-9
Rezvani M, Aiken J and SALEEM A. Effect of a Sugar-Free Branched Chain Amino Acid-Containing Sports Drink on Acute High Intensity Anaerobic Performance. Journal of Innovation in Polytechnic Education. 2021. Manuscript submitted
Sidhom K†, Obi PO†, and SALEEM A. A Review of Exosomal Isolation Methods: Is Size Exclusion Chromatography the Best Option? Int. J. Mol. Sci. 2020, 21(18), 6466, doi: 10.3390/ijms21186466.†co-first authors
Obi PO, Bydak B, Safdar A and SALEEM A. Extracellular vesicles and circulating miRNAs – exercise-induced mitigation of obesity and associated metabolic diseases. In Tappia et al. (eds.), Pathophysiology of Obesity-Induced Health Complications in Series: Advances in Biochemistry in Health and Disease, Winnipeg: Springer International Publishing, Chpt 4; v19, pp. 59-80. Jan 2020, https://doi.org/10.1007/978-3-030-35358-2_4.
Blakely K, Mero P, Arnold R, SALEEM A, Misquitta C, Kasimer D, Kumar S, Uetrecht A, Brown KA, Datti A, Hood DA, Kim P, and Moffat J. Cell cycle regulation of mitochondrial protein import revealed by genome-scale pooled bimolecular fluorescence complementation screening, Sep 2019. bioRxiv, 770669; doi: https://doi.org/10.1101/770669.
SALEEM A, Bourgeois JM, Khan MI, Safdar A, Azzopardi P, Rusiecki D, and Tarnopolsky MA. Exosome-mRNA therapy restores dystrophin expression and improves muscle function in mdx mice. University of Manitoba Libraries MSpace. 2019
http://hdl.handle.net/1993/34345.
Nazli A†, Safdar A†, SALEEM A, Akhtar M, Brady LI, Schwartzentruber J, FORGE Canada Consortium, and Tarnopolsky MA. A mutation in the TMEM65 gene results in mitochondrial myopathy with severe neurological manifestations. Eur J Hum Genet. 2017 Jun;25(6):744-751. DOI: 10.1038/ejhg.2017.20. †co-first authors
Safdar A, Annis S, Kraytsberg Y, Laverack C, SALEEM A, Popadin K, Woods DC, Tilly JL and Khrapko K. Amelioration of premature aging in mtDNA mutator mouse by exercise: the interplay of oxidative stress, PGC-1a, p53 and DNA damage. Curr Opin Genet Dev. 2016 Jun;38:127-132. DOI: 10.1016/j.gde.2016.06.011.
Safdar A, SALEEM A, and Tarnopolsky MA. The potential for endurance exercise-derived exosomes to treat metabolic diseases – Good things come in small packages. Nat Rev Endocrinol, 2016 Sep;12(9):504-17. DOI: 10.1038/nrendo.2016.76.
Clark-Matott J, SALEEM A, Dai Y, Ma X, Safdar A, Tarnopolsky MA and Simon DK. Metabolomic analysis of exercise effects in the PolG mtDNA mutator mouse brain. Neurobiol Aging. 2015 Nov;36(11):2972-2983. DOI: 10.1016/j.neurobiolaging.2015.07.020.
Collu-Marchese M, Shuen M, Pauly M, SALEEM A, and Hood DA. The regulation of mitochondrial transcription factor A (Tfam) expression during skeletal muscle differentiation. Biosci Rep. 2015 May 19;35(3). pii: e00221. DOI: 10.1042/BSR20150073.
SALEEM A, Safdar A, Kitaoka Y, Ma X, Marquez OS, Akhtar M, Suri R, Nazli A, Turnbull J and Tarnopolsky MA. Polymerase gamma mutator mice rely on increased glycolytic flux for energy production. Mitochondrion 2015 Mar;21:19-26. DOI: 10.1016/j.mito.2014.12.001.
SALEEM A, Iqbal S, Zhang Y and Hood DA. Effect of p53 on mitochondrial morphology, mitophagy and assembly in skeletal muscle. Am J Physiol Cell Physiol. 2015 Feb 15;308(4):C319-29. DOI: 10.1152/ajpcell.00253.2014.
SALEEM A, Carter HN, and Hood DA. p53 is necessary for the adaptive changes in the cellular milieu subsequent to an acute bout of endurance exercise. Am J Physiol Cell Physiol. 2014 Feb 1;306(3):C241-9. DOI: 10.1152/ajpcell.00270.2013.
Zhang Y, Iqbal S, O’Leary MFN, Menzies KJ, SALEEM A, Ding S, and Hood DA. Altered mitochondrial morphology and defective protein import reveals novel roles for Bax and/or Bak in skeletal muscle. Am J Physiol Cell Physiol. 2013 Sep;305(5):C502-11. DOI: 10.1152/ajpcell.00058.2013.
SALEEM A, and Hood DA. Exercise induces p53 translocation to the mitochondria and promotes p53-Tfam-mtDNA complex formation. J Physiol, 2013 Jul 15;591(Pt 14):3625-36. DOI: 10.1113/jphysiol.2013.252791.
Menzies KJ, Singh K, SALEEM A, and Hood DA. Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. J Biol Chem. 2013 Mar 8;288(10):6968-79. DOI: 10.1074/jbc.M112.431155.
*Chosen as the Best Paper of JBC 2013 in the category ‘metabolism’
SALEEM A, Carter HN, Iqbal S and Hood DA. Role of p53 Within the Regulatory Network Controlling Muscle Mitochondrial Biogenesis. Exerc Sport Sci Rev. 2011 Oct;39(4):199-205. DOI: 10.1097/JES.0b013e31822d71be.
SALEEM A, and Safdar A. Exercise-induced Histone Acetylation – Playing Tag with the Genome. J Physiol, 2010 Mar 15;588(Pt 6):905-6. DOI: 10.1113/jphysiol.2009.185595.
For a full list of publications, see Dr. Saleem's Google Scholar profile.